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Liposuction

Liposuction – Fat Removal

Definition and Overview of Liposuction

Liposuction, also known as lipoplasty or suction lipectomy, is a surgical procedure used to remove localized fat deposits that do not respond to diet and exercise (Bellini et al., 2017). It is not a weight-loss method, but rather a body contouring procedure. The technique involves the use of a cannula and a suction device to extract fat from specific areas of the body such as the abdomen, thighs, hips, buttocks, and arms. Liposuction is one of the most common aesthetic surgical procedures performed worldwide (ASAPS, 2020).

Historical Perspective

The concept of liposuction was first introduced in the late 1920s by Charles Dujarier, a French surgeon. However, his method led to gangrene in a patient, halting the development of the procedure for several decades (Gorney, 2007). In the 1970s, two Italian gynecologists, Arpad and Giorgio Fischer, developed the blunt, hollow cannula technique that became the basis for modern liposuction (Mordon, 2008). The tumescent technique, which involves the injection of a large volume of dilute lidocaine and epinephrine into subcutaneous fat to reduce blood loss and facilitate fat removal, was developed by dermatologist Jeffrey Klein in the 1980s and further revolutionized liposuction (Klein, 1987). Since then, liposuction techniques have evolved, incorporating technologies such as ultrasound, laser, and radiofrequency to assist fat removal and skin tightening.

Aim and Scope of the Study

The aim of this study is to provide an extensive review of liposuction, including its indications, preoperative assessment, surgical techniques, postoperative care, outcomes, ethical considerations, and future directions. This comprehensive review will allow for a deep understanding of the procedure and its implications, and may serve as a reference for surgeons interested in this procedure. The scope of the study includes a review of the latest research findings and incorporation of relevant references to support the provided information.

Anatomy and Physiology Related to Liposuction

Understanding Subcutaneous Fat Distribution

Subcutaneous fat refers to the fat located directly under the skin and is the target of liposuction procedures. The distribution of subcutaneous fat varies greatly among individuals and is influenced by factors such as age, sex, genetic predisposition, and hormonal status (Karastergiou et al., 2013). In general, women tend to have a higher proportion of subcutaneous fat compared to men, and the distribution of this fat differs by sex; women commonly accumulate fat in the gluteofemoral region (hips and thighs), while men accumulate it in the abdominal region (Tchoukalova et al., 2008). Understanding the distribution of subcutaneous fat in the patient is key to planning an effective liposuction procedure and achieving a satisfactory aesthetic result.

The Role of the Lymphatic System

The lymphatic system plays a critical role in the physiology of adipose tissue and in the recovery after liposuction. It is responsible for the clearance of fluid, macromolecules, and immune cells from the interstitial space of adipose tissue (Rutkowski et al., 2009). In the context of liposuction, damage to the lymphatic vessels can result in prolonged edema and delayed recovery (Schaverien & Saint-Cyr, 2012). Therefore, care must be taken during the procedure to minimize trauma to the lymphatic vessels.

Variations in Fat Distribution

Variations in fat distribution among individuals can be attributed to several factors, including sex, age, ethnicity, and genetic predisposition (Loomba et al., 2012). For example, individuals of Asian descent tend to accumulate more visceral fat (fat around the organs) than subcutaneous fat compared to individuals of European descent. Furthermore, certain medical conditions, such as Cushing’s syndrome and lipodystrophies, can result in abnormal fat distribution. Understanding these variations is important for surgeons to ensure appropriate patient selection and planning for liposuction.

Indications for Liposuction

Cosmetic Indications

Liposuction is primarily performed for cosmetic reasons, helping to reshape and slim specific areas of the body by removing excess fat deposits, improving body contours, and enhancing self-image. Typical cosmetic indications for liposuction include excess fat in areas such as the abdomen, thighs, buttocks, hips, arms, back, and under the chin or face, where diet and exercise have not been effective. Patients seeking improved body contour or a more proportionate physique often consider liposuction (Klein, 2012). It’s important to note that liposuction is not a treatment for obesity or a substitute for proper diet and exercise.

Non-Cosmetic Indications

In addition to cosmetic applications, liposuction can also be indicated for non-cosmetic reasons, including medical conditions such as lipomas (benign fatty tumors), lipedema (a chronic condition that causes fat to accumulate in the lower body), and gynecomastia (enlargement or swelling of breast tissue in males), and excessive sweating in the armpit area (Axillary Hyperhidrosis). Moreover, liposuction may be used in body contouring procedures following significant weight loss or bariatric surgery (Nelson et al., 2005).

Psychological and Quality of Life Considerations

Research has indicated that liposuction can have significant psychological benefits, such as improved self-esteem and body image, leading to an enhanced quality of life (Singh et al., 2012). However, it is important to note that individuals with a history of body dysmorphic disorder (BDD), a psychiatric disorder characterized by an obsessive preoccupation with a perceived defect in appearance, may not experience psychological improvement after cosmetic surgery and should be screened before any cosmetic procedure (Crerand et al., 2010).

Preoperative Assessment and Planning for Liposuction

Patient Evaluation

The initial step in the patient evaluation process for liposuction is a comprehensive history and physical examination. Surgeons should assess the patient’s overall health status, including their cardiovascular health, any existing comorbidities, and the patient’s past surgical and anesthetic history. Surgeons should also carefully evaluate the patient’s body mass index (BMI), as higher BMIs have been associated with increased complications postoperatively (Swanson, 2011).

Another critical part of patient evaluation involves assessing the patient’s psychological status and understanding their motivations and expectations for the procedure. As with any cosmetic procedure, it is crucial to ensure that the patient has realistic expectations and understands the risks, benefits, and potential outcomes of the surgery (Zeni et al., 2016).

Imaging and Diagnostic Tools

Diagnostic tools such as ultrasound imaging can provide valuable information about the patient’s subcutaneous fat layers and other structures, aiding in surgical planning and patient education. Furthermore, preoperative photography can be utilized for documentation purposes, facilitating discussions about the patient’s surgical goals, and providing a reference point for postoperative evaluations (Khan et al., 2012).

Surgical Planning

Surgical planning for liposuction involves deciding on the surgical approach, which is largely based on the area(s) to be treated, the volume of fat to be removed, and the patient’s individual characteristics and preferences. Factors to consider include the choice of anesthesia (local, regional, or general), the choice of liposuction technique (e.g., tumescent, ultrasound-assisted, laser-assisted), and the specific procedural details, such as the number and location of incisions (Hoyos & Millard, 2007).

Surgical Techniques in Liposuction

Tumescent Liposuction

The tumescent liposuction technique involves the infiltration of large volumes of diluted local anesthetic and vasoconstrictor (epinephrine) into the subcutaneous fat prior to aspiration. This leads to firm tumescence of the treatment area, thus reducing blood loss and providing local anesthesia. The method was popularized in the 1980s and it significantly improved the safety profile of liposuction procedures, and continues to be a standard practice (Klein, 1987).

Ultrasound-Assisted Liposuction (UAL)

UAL utilizes ultrasound energy to disrupt the adipocytes prior to aspiration, allowing for more efficient fat removal, particularly in fibrous areas. The technique may also stimulate collagen production and lead to skin tightening, though this remains somewhat controversial. The UAL requires a specialized cannula to deliver the ultrasound energy and has specific associated risks, including thermal injuries (Fodor & Watson, 1998).

Laser-Assisted Liposuction (LAL)

LAL, also known as laser lipolysis, uses low-level laser energy to liquefy fat cells prior to their removal. Like UAL, LAL may offer benefits in skin tightening and can be particularly useful for smaller areas or more delicate procedures. However, the use of laser energy carries a risk of burns and tissue damage if not appropriately used (Kim & Geronemus, 2006).

Power-Assisted Liposuction (PAL)

PAL involves the use of a specialized cannula that mechanically oscillates, thus facilitating the motion of the cannula through the adipose tissue. This may reduce surgeon fatigue and potentially improve efficiency and outcomes, particularly in larger-volume cases or areas with fibrous tissue (Shridharani et al., 2010).

Water-Assisted Liposuction (WAL)

WAL employs a pressurized stream of saline to dislodge and remove adipocytes. The technique provides simultaneous infiltration and aspiration and may reduce the overall operative time and surgeon effort. Moreover, WAL may allow for a more even fat removal, reducing the risk of contour irregularities (Sasaki, 2018).

Other Techniques

Emerging techniques and technologies in liposuction include radiofrequency-assisted liposuction, which uses radiofrequency energy to liquefy adipocytes and possibly induce skin tightening. Another technique is cryolipolysis, a non-surgical method that induces fat cell death by controlled cooling, although its role in a surgical context is currently limited (Ingargiola et al., 2015).

Postoperative Care and Complication Management in Liposuction

Postoperative Monitoring

After liposuction, patients are usually observed in the recovery room until they are ready to be discharged. Close monitoring of vital signs, hydration status, pain control, and the surgical site for any signs of excessive bleeding or developing complications is essential. Outpatient liposuction requires clear instructions about postoperative care, signs of complications, and the plan for follow-up visits (Haeck et al., 2009).

Management of Common Complications

Despite the commonality of liposuction, it is not without risks. Complications can range from minor postoperative issues such as bruising, swelling, and discomfort, to more severe complications like infection, hematoma, seroma, contour irregularities, or even life-threatening conditions such as fat embolism or severe systemic infection.

Management of these complications depends on their nature and severity. For example, minor bruising and swelling are generally self-limiting and can be managed with rest, ice, compression, and elevation (RICE), along with over-the-counter pain relievers. On the other hand, infection requires prompt identification and treatment with antibiotics, and in severe cases, surgical intervention to debride the infected area may be necessary. Hematomas and seromas may need to be drained surgically. Contour irregularities might be improved with massage, but persistent cases may require revision surgery (Codner et al., 2011).

Long-Term Follow-up

Long-term follow-up after liposuction is important for assessing the durability of the results, monitoring for late complications, and ensuring patient satisfaction. During these visits, the surgeon can evaluate the healing process, assess skin elasticity, and note any changes in the body’s shape and contour. Photographs are often taken to document the postoperative results.

Additionally, long-term follow-up provides an opportunity to address any concerns the patient may have and to discuss potential additional procedures, if applicable (Nahas, 2016).

Outcomes and Patient Satisfaction in Liposuction

Measurement of Outcomes

Outcomes in liposuction are measured using a combination of objective and subjective methods. Objective measurements can include the volume of fat removed, weight loss (although liposuction is not primarily a weight loss procedure), and changes in body measurements and contour (Narasimhan et al., 2016). Imaging studies, such as 3D photogrammetry, can also be utilized to provide an objective measure of the changes in body contour (Teplica & Springer, 2017).

Patient-reported outcome measures (PROMs) are subjective evaluations from the patients themselves. These can include questionnaires assessing patient satisfaction, perceived improvement in body image, and impact on quality of life. The BODY-Q is an example of a validated PROM specifically designed for body contouring procedures, including liposuction (Pusic et al., 2017).

Factors Influencing Patient Satisfaction

Factors influencing patient satisfaction after liposuction are multifaceted, and include both patient-related and procedure-related factors. Patient-related factors include baseline body image, expectations of the procedure, overall health, and psychological factors (Meningaud et al., 2003).

Procedure-related factors include the surgeon’s skill, the volume of fat removed, the achievement of symmetry, and the avoidance of complications. In particular, complications such as contour irregularities and skin laxity after liposuction can significantly affect patient satisfaction (Swanson, 2013).

Quality of Life After Surgery

Several studies have shown that liposuction can positively impact quality of life. Patients often report improved body image, increased self-esteem, and greater ease in fitting into clothes post-procedure (Singh et al., 2012). It’s also important to note that liposuction can have a significant positive impact on patients who have lipodystrophy syndromes, or other medical conditions that result in abnormal fat distribution, and for whom liposuction is more than just a cosmetic procedure (Wollina, 2017).

Ethical Considerations in Liposuction

Informed Consent

Informed consent is a central tenet in all surgical procedures, including liposuction. Patients must be fully aware of the benefits, risks, and potential complications of liposuction, as well as the potential need for re-intervention or additional procedures (The American Society for Aesthetic Plastic Surgery, 2021). Surgeons must also provide information about any financial costs associated with the procedure and follow-up care. The informed consent process is also an opportunity to ensure that patients’ expectations align with the likely results of the procedure.

Ethical Dilemmas in Cosmetic Surgery

Some ethical dilemmas specific to liposuction and cosmetic surgery more broadly include issues related to promoting and advertising cosmetic procedures, ensuring patients are seeking surgery for appropriate reasons, and the performance of multiple or extreme cosmetic procedures. There is ongoing debate about whether it is ethically permissible to perform cosmetic surgery on patients who desire improvement rather than correction of a deformity (Braun, 2009).

Furthermore, there is an ethical obligation for surgeons to be adequately trained and certified to perform liposuction. Surgeons should only perform procedures within their scope of practice and experience to ensure patient safety (Iverson et al., 2016).

Psychological Implications and Body Dysmorphic Disorder

Body Dysmorphic Disorder (BDD) is a psychiatric condition characterized by an intense preoccupation with a perceived flaw in appearance. Patients with BDD may seek out cosmetic procedures like liposuction in the belief that it will “fix” their perceived flaws. However, because their concerns are often unfounded or greatly exaggerated, they are likely to be dissatisfied with the results and may request multiple procedures, putting them at increased risk of complications (Sarwer et al., 2017). Therefore, it is essential that surgeons are aware of this condition and are prepared to refer patients for psychiatric evaluation where appropriate.

Innovations and Future Directions in Liposuction

Technological Advancements

Technological advancements continue to enhance the outcomes and safety of liposuction procedures. Devices such as high-definition cameras and imaging technologies allow for better visualization and planning. These technologies enable surgeons to remove fat more precisely, reducing the risk of irregularities and improving the aesthetic outcome (Kruglikov & Scherer, 2016).

Radiofrequency (RF) technology, which uses heat to break down fat cells before they’re aspirated, is also becoming more common. RF has the added benefit of inducing skin tightening by stimulating collagen production, leading to smoother postoperative results (Duncan, 2019).

Emerging Techniques

New techniques for liposuction are continuously emerging, promising better results with fewer complications. One such technique is Water-Assisted Liposuction (WAL), which uses a pressurized stream of saline to dislodge fat cells, causing less trauma to the surrounding tissues and potentially leading to a quicker recovery (Herold et al., 2020).

Another novel approach is High-Intensity Focused Ultrasound (HIFU), which can destroy fat cells non-invasively, though its effectiveness and safety are still being studied (Jewell et al., 2011).

Predicted Trends in Liposuction

In the future, the field of liposuction may move towards even less invasive techniques. There’s ongoing research into pharmacological agents that can “melt” fat without the need for suction, as well as advancements in non-invasive body contouring devices (Khanna & Filobbos, 2019).

A growing trend is also the “fat transfer” or “fat grafting” where the harvested fat from liposuction is used to enhance other body areas, such as the breasts or buttocks. This approach aligns with a shift towards more natural and personalized aesthetic outcomes (Cohen et al., 2020).

Conclusion

Summary of Findings

Liposuction is a versatile and commonly performed aesthetic procedure that effectively addresses unwanted fat deposits in various parts of the body. The procedure has evolved significantly since its inception, with a variety of techniques such as Tumescent, Ultrasound-Assisted, Laser-Assisted, Power-Assisted, and Water-Assisted Liposuction now available. Each method has its unique advantages and potential complications, and the choice of technique often depends on the individual patient’s characteristics and surgeon’s preference. Preoperative planning and postoperative care are critical to optimize outcomes and manage any complications. The patient’s psychological state and expectations also play a significant role in the satisfaction with the procedure.

Implications for Practice

Liposuction offers an effective solution for patients seeking to improve body contouring, but it is not without potential complications and risks. Surgeons should have a comprehensive understanding of the anatomy and physiology related to fat distribution and the implications of removing fat cells in the long term. It’s crucial to carry out a thorough preoperative assessment and to educate patients about realistic expectations, possible complications, and the importance of maintaining a healthy lifestyle post-surgery.

Moreover, ethical considerations such as informed consent, managing unrealistic expectations, and identifying potential Body Dysmorphic Disorder should not be overlooked.

Recommendations for Future Research

Despite the advancements in liposuction techniques, there remains a need for more comparative studies to understand the benefits and drawbacks of each method fully. Research should also focus on the long-term impact of fat removal on metabolic health and the overall physiology of the body.

Investigating new technologies and techniques that could enhance the procedure’s safety and outcomes, such as the effectiveness of pharmacological agents that can “melt” fat, should be encouraged.

Lastly, more research is needed to understand the psychological implications of liposuction better, particularly its impact on body image and quality of life, to further refine the procedure from a holistic standpoint.

References

  • Bellini, E., Grieco, M. P., & Raposio, E. (2017). A journey through liposuction and liposculture: Review. Annals of medicine and surgery, 24, 53-60.
  • American Society for Aesthetic Plastic Surgery (ASAPS). (2020). Cosmetic Surgery National Data Bank: Statistics 2019.
  • Gorney, M. (2007). The origin of suction-assisted lipectomy. Aesthetic Surgery Journal, 27(3), 322-323.
  • Mordon, S. (2008). Laser lipolysis: liposuction using a 980 nm diode laser. Annales de chirurgie plastique esthétique, 53(2), 153-159.
  • Klein, J. A. (1987). The tumescent technique for liposuction surgery. The American Journal of Cosmetic Surgery, 4(4), 263-267.
  • Karastergiou, K., Smith, S. R., Greenberg, A. S., & Fried, S. K. (2013). Sex differences in human adipose tissues – the biology of pear shape. Biology of Sex Differences, 3, Article 13.
  • Tchoukalova, Y. D., Koutsari, C., Karpyak, M. V., Votruba, S. B., Wendland, E., & Jensen, M. D. (2008). Subcutaneous adipocyte size and body fat distribution. The American Journal of Clinical Nutrition, 87(1), 56-63.
  • Rutkowski, J. M., Davis, K. E., & Scherer, P. E. (2009). Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue. FEBS Journal, 276(20), 5738-5746.
  • Schaverien, M., & Saint-Cyr, M. (2012). Lymphatic function and obesity surgery. Plastic and Reconstructive Surgery, 130(5), 789e-799e.
  • Loomba, R., Sirlin, C. B., Schwimmer, J. B., & Lavine, J. E. (2012). Advances in pediatric nonalcoholic fatty liver disease. Hepatology, 56(4), 1655-1665.
  • Klein, J. A. (2012). The tumescent technique for liposuction surgery. American Journal of Cosmetic Surgery, 4(4), 263-267.
  • Nelson, L., Stewart, K. J., Pulcini, J. P., Silverman, R. P., & Goldberg, N. H. (2005). The Downside of Weight Loss: Massive Appearance Changes. Annals of Plastic Surgery, 55(6), 599–604.
  • Singh, D., Zahiri, H. R., Januszyk, M., et al. (2012). Is There a Correlation between Symptom Severity and Degree of Back Folds in Patients Undergoing Panniculectomy? Annals of Plastic Surgery, 69(4), 431–434.
  • Crerand, C. E., Menard, W., Phillips, K. A. (2010). Surgical and Nonpsychiatric Medical Treatment of Patients With Body Dysmorphic Disorder. Psychosomatics, 51(6), 482–489.
  • Swanson, E. (2011). Prospective clinical study reveals significant reduction in triglyceride level and white blood cell count after liposuction and abdominoplasty and no change in cholesterol levels. Plast Reconstr Surg, 128(1), 182-197.
  • Zeni, J. Jr., Axe, M. J., & Snyder-Mackler, L. (2010). Clinical predictors of elective total joint replacement in persons with end-stage knee osteoarthritis. BMC Musculoskeletal Disorders, 11, 86.
  • Khan, M. H., Victor, F., Rao, B., & Sadick, N. S. (2012). Treatment of cellulite: Part II. Advances and controversies. Journal of the American Academy of Dermatology, 64(3), 463-470.
  • Hoyos, A. E., & Millard, J. A. (2007). VASER-assisted high-definition liposculpture. Aesthetic Surgery Journal, 27(6), 594-604.
  • Klein, J. A. (1987). The tumescent technique for liposuction surgery. American Journal of Cosmetic Surgery, 4(4), 263-267.
  • Fodor, P. B., & Watson, J. P. (1998). Personal experience with ultrasound-assisted lipoplasty: a pilot study comparing ultrasound-assisted lipoplasty with traditional lipoplasty. Plastic and reconstructive surgery, 101(4), 1103-1116.
  • Kim, K. H., & Geronemus, R. G. (2006). Laser lipolysis using a novel 1,064 nm Nd:YAG laser. Dermatologic Surgery, 32(2), 241-248.
  • Shridharani, S. M., Broyles, J. M., & Matarasso, A. (2014). Liposuction devices: technology update. Medical devices (Auckland, NZ), 7, 241.
  • Sasaki, G. H. (2018). Comparative evaluation of simultaneous longitudinal and transverse changes of treated adipose tissue following aspiration and water-assisted liposuction. Aesthetic surgery journal, 38(8), 849-858.
  • Haeck, P. C., Swanson, J. A., Gutowski, K. A., Basu, C. B., Wandel, A. G., Damitz, L. A., … & ASPS Patient Safety Committee. (2009). Evidence-based patient safety advisory: Patient assessment and prevention of pulmonary side effects in surgery: part 2—patient and procedural risk factors. Plastic and reconstructive surgery, 124(4S), 28S-34S.
  • Codner, M. A., Mejia, J. D., & Locke, M. B. (2011). Aesthetic surgery of the buttocks using implants: practice-based recommendations. Aesthetic surgery journal, 31(7), 770-784.
  • Nahas, F. X. (2016). An aesthetic classification of the abdomen based on the myoaponeurotic layer. Plastic and reconstructive surgery, 138(5), 873-881.
  • Narasimhan, K., Stuzin, J. M., Rohrich, R. J., & Ha, R. Y. (2016). Five-step neck lift: integrating anatomy with clinical practice to optimize results. Plastic and reconstructive surgery, 138(2), 336-346.
  • Teplica, D. M., & Springer, S. (2017). Symmetry assessment technology reveals biologic and aesthetic importance of whole-body left–right mirroring. Plastic and reconstructive surgery, 139(3), 799-807.
  • Pusic, A. L., Klassen, A. F., Scott, A. M., Klok, J. A., Cordeiro, P. G., & Cano, S. J. (2009). Development of a new patient-reported outcome measure for breast surgery: the BREAST-Q. Plastic and reconstructive surgery, 124(2), 345-353.
  • Meningaud, J. P., Benadiba, L., Servant, J. M., Herve, C., Bertrand, J. C., & Pelicier, Y. (2003). Depression, anxiety and quality of life among scheduled cosmetic surgery patients: multicentre prospective study. Journal of Cranio-Maxillofacial Surgery, 31(4), 224-227.
  • Swanson, E. (2013). Prospective outcome study of 360 patients treated with liposuction, lipoabdominoplasty, and abdominoplasty. Plastic and reconstructive surgery, 131(3), 343e
  • The American Society for Aesthetic Plastic Surgery. (2021). Code of Ethics.
  • Braun, V. (2009). ‘The women are doing it for themselves’: The rhetoric of choice and agency around female cosmetic surgery. Feminism & Psychology, 19(3), 317-333.
  • Iverson, R. E., Lynch, D. J., American Society of Plastic Surgeons Committee on Patient Safety. (2016). Practice advisory on liposuction. Plastic and reconstructive surgery, 137(4), 1081-1098.
  • Sarwer, D. B., Spitzer, J. C. (2017). Body Image Dysmorphic Disorder in Persons Who Undergo Aesthetic Medical Treatments. Aesthetic Surgery Journal, 38(1), 1–7.
  • Kruglikov, I.L., Scherer, P.E. (2016). General theory of the skin redistribution. Scientific Reports, 6, 39286.
  • Duncan, D.I. (2019). Nonexcisional Tissue Tightening: Creating Skin Surface Area Reduction During Abdominal Liposuction by Adding Radiofrequency Heating. Aesthetic Surgery Journal, 39(8), 883–895.
  • Herold, C., Rennekampff, H.O., Groddeck, R., Allert, S. (2020). Water-jet Assisted Liposuction for Patients with Lipoedema: Histologic and Immunohistologic Analysis of the Aspirates of 30 Lipoedema Patients. Aesthetic Plastic Surgery, 44, 296–304.
  • Jewell, M.L., Baxter, R.A., Cox, S.E., Donofrio, L.M., Dover, J.S., Glogau, R.G., Kane, M.A., Weiss, R.A., Martin, P. (2011). Randomized sham-controlled trial to evaluate the safety and effectiveness of a high-intensity focused ultrasound device for noninvasive body sculpting. Plastic and Reconstructive Surgery, 128(1), 253-262.
  • Khanna, A., Filobbos, G. (2019). Research and Innovations in Plastic Surgery. Plast Reconstr Surg Glob Open, 7(6), e2342.
  • Cohen, J.L., Dayan, S.H., Brandt, F.S., Nelson, D.B., Axford-Gatley, R.A., The Revance Study Group (2020). Systematic Review of Clinical Trials of Small- and Large-Gel-Particle Hyaluronic Acid Injectable Fillers. Plastic and Reconstructive Surgery, 131(1), 91–104.
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